Okay, i originally said Hendrix, which was a bit obvious.But he did play a right handed guitar left handed(thus upside down),played rythmn & lead whilst only backed by bass & drums,and threw in vocals as well.If i had to vote for someone not so obvious it would have to be Will Seargent of the Bunnymen,just for the amazing & slightly trippy left field solos he did on the albums "Crocodiles","Heaven Up Here"&"Porcupine".
